NIST- SRM 921a Cortisol (Hydrocortisone)

NIST- SRM 921a  Cortisol (Hydrocortisone)

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This Standard Reference Material (SRM) is certified as a neat chemical material of known purity. It is intended for use in the calibration and standardization of clinical measurement laboratory procedures for determining quantities of cortisol. A unit of SRM 921a consists of 1 g of high-purity crystalline cortisol. Certified Cortisol Mass Fraction: 99.3 % ± 0.4 %

A NIST certified value is a value for which NIST has the highest confidence in its accuracy in that all known or suspected sources of bias have been investigated or taken into account [1]. The measurand is the mass fraction of cortisol (expressed as percent) [2] and the uncertainty is expressed as the 95 % confidence interval (U95%) [3,4]. The standard uncertainty (u) of the certified value is 0.2 %. Metrological traceability of the certified value is to the International System of Units (SI) through realization of measurement units for chemical mass fraction (expressed as percentage). The certified value was determined using a quantitative 1 H-nuclear magnetic resonance spectroscopy (1H-qNMR) primary ratio measurement procedure [5,6].

本标准参考物质(SRM)经认证为已知纯度的纯化学物质。它旨在用于临床测量实验室程序的校准和标准化,以确定皮质醇的数量。SRM 921a的单位由1g高纯度结晶皮质醇组成。

认证皮质醇质量分数:99.3%±0.4%

NIST认证值是指NIST对其准确性具有最高信心的值,因为所有已知或怀疑的偏差源都已被调查或考虑[1]。被测物是皮质醇的质量分数(以百分比表示)[2],不确定度表示为95%置信区间(U95%)[3,4]。认证值的标准不确定度(u)为0.2%。通过实现化学质量分数的测量单位(以百分比表示),认证值的计量可追溯性为国际单位制(SI)。使用定量1H核磁共振波谱(1H-qNMR)一次比值测量程序确定认证值[5,6]。

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